5 interactive labs · AS & A Level Biology 9700
· Follow one marked parcel of blood through the heart, lungs and body, colour the vessels by direction or by oxygen, and compare the pressures.
Follow one marked parcel of blood through the heart, lungs and body, colour the vessels by direction or by oxygen, and compare the pressures.
You will be able to
Syllabus learning outcomes: 8.1.1, 8.1.2, 8.3.1, 8.3.2
· Compare plan diagrams of arteries, veins and capillaries, test what elastic tissue does to the pressure, and identify cells in a blood film.
Compare plan diagrams of arteries, veins and capillaries, test what elastic tissue does to the pressure, and identify cells in a blood film.
You will be able to
Syllabus learning outcomes: 8.1.3, 8.1.4, 8.1.5, 8.1.6
· Zoom into a capillary, change the blood pressure and the plasma proteins, and track where water, solutes, cells and proteins go.
Zoom into a capillary, change the blood pressure and the plasma proteins, and track where water, solutes, cells and proteins go.
You will be able to
Syllabus learning outcomes: 8.1.6, 8.1.7
· Step through one heartbeat with the chambers, the wave of excitation, the pressure traces and the valves all linked, and predict each valve from the pressures.
Step through one heartbeat with the chambers, the wave of excitation, the pressure traces and the valves all linked, and predict each valve from the pressures.
You will be able to
Syllabus learning outcomes: 8.3.1, 8.3.3, 8.3.4
· Move blood from the lungs to resting and active tissue, measure the oxygen unloaded, shift the curve with CO₂, then step CO₂ through a red blood cell.
Move blood from the lungs to resting and active tissue, measure the oxygen unloaded, shift the curve with CO₂, then step CO₂ through a red blood cell.
You will be able to
Syllabus learning outcomes: 8.2.1, 8.2.2, 8.2.3, 8.2.4, 8.2.5, 8.2.6
Each link is a piece of biology that carries an idea from one lab into another. Follow one to use what you found here in a new setting.
A sprinter's leg muscles go from rest to maximum effort in a few seconds. Follow oxygen from the alveoli to the mitochondria and ATP to the sarcomere.
Ventilation rate and blood flow to the lungs both rise. Why does that keep oxygen uptake high?
Fresh air keeps the alveolar partial pressure of oxygen high and flowing blood keeps the capillary partial pressure low, so a steep diffusion gradient is maintained across the thin squamous epithelium.
Working muscle has a higher partial pressure of carbon dioxide. How does that change oxygen unloading?
More carbon dioxide gives more hydrogen ions (carbonic anhydrase), which bind haemoglobin and lower its affinity for oxygen: the Bohr shift moves the curve right, so more oxygen is released at the same partial pressure.
Where is that oxygen used, and why is it essential for ATP synthesis?
On the inner mitochondrial membrane oxygen accepts electrons at the end of the chain and forms water; without it the chain stops, protons are no longer pumped and ATP synthase has no gradient to use.
Oxygen supply cannot keep up. How does the muscle still make some ATP?
Pyruvate is reduced to lactate, which regenerates NAD so glycolysis can continue; only the ATP from glycolysis is made, so the yield per glucose is far smaller.
What does each contraction cycle use ATP for?
ATP binds the myosin head so it detaches from actin, and its hydrolysis re-cocks the head; calcium ions released from the sarcoplasmic reticulum expose the binding sites.
